NSAIDs Dangerous
Acute GI permeability responses to different NSAIDs – (11-05-01)
Acute GI permeability responses to different NSAIDs
This is one of those topics regarding NSAIDs that has such a potentially harmful impact on our systemic health and yet is never address and few patients are aware of it. Note that the dosages used in this study were not large and changes were seen within two days. Worst in this class was naproxen (aka Alieve…) which also affected gastric permeability. Maintaining intestinal permeability is so important to keeping the immune response to things we eat to a minimum. With increased intestinal permeability (“leaky gut syndrome”) the immune system is very likely to react and overreact to food antigens; this abnormal response sets the tone for immune upregulation and autoimmune responses. All this from two days of anti-inflammatories. Do they seem so harmless now?
Gut — Abstracts: Smecuol et al. 49 (5): 650
