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Advanced glycation end-products on PMN superoxide production – (12-17-01)
James Bogash
Advanced glycation end-products on PMN superoxide production
To put this in English, abnormally high levels of glucose in the blood stream will irreversibly damage proteins, a process called glycosylation. PMNs are white blood cells that help fight off bacterial infections; they do this by ingesting the bacteria and destroying them with a compound called superoxide.
Thus, this study connects the link between diabetics and increased susceptibility to bacterial infections. I would widen the net to dysglycemic patients as well; these patients will also have elevated glucose and insulin levels.
Synergy : European Journal of Clinical Investigation 31 (12), 1064-1069
