Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates
Regular readers of updates know that I consider mitochondrial dysfunction as the root of all evil when it comes to chronic diseases. Anything we can do to protect the mitochondria will have a positive effect on health and longevity. It has been well established that calorie restriction is the ONLY intervention known to extend lifespan in mammals. This means that your 1200 calories / day comes from broccoli, not a Big Mac and super-sized fries. It is believed that one of the mechanisms that CR works is by improving the number and efficiency of the mitochondria.
This study adds to that, finding that CR in primates leads to reduced immune senescence, or shutting down of the immune system with age. A healthier immune system means persistant cancer surveilance and retained ability to fight off infectious diseases. Definitely a good thing. The research has also played around with the concept of alternate day CR as well as short term fasting coupled with aerobic exercise. Some researchers actually disagree with the concept of CR extending lifespan. Rather, they believe that increased caloric intake SHORTENS a normal lifespan… In other words, our calories are killing us.
