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Insulin
Arterial Stiffness Increases With Deteriorating Glucose Tolerance Status – (05-05-03)
James Bogash
Arterial Stiffness Increases With Deteriorating Glucose Tolerance Status.
More and more evidence is mounting for the contribution that insulin resistance plays in vascular dynamics, both directly and indirectly. Insulin resistance slows the breakdown of ADMA levels, thus blocking nitric oxide’s vasodilatory effects. Hyperinsulinemia lowers contractility of blood vessels. Insulin resistance increases homocysteine levels which then affects formation of plaque on the arterial walls. The list goes on, and one thing is clear–ANY patient with any degree of high blood pressure needs to address the issue of insulin resistance.
Circulation — Abstracts: Henry et al. 107 (16): 2089
