Increased Rates of Chromosome Breakage in BRCA1 Carriers Are Normalized by Oral Selenium Supplementation
I know that I have had at least one patient come through my office that had prophalactic bilateral mastectomy because she carried the BRCA gene. I think few things demonstrate the influence that environment has on our genes than this situation. We have also seen that tamoxifen use attenuates the increased risk found in patients with the BRCA1 and 2 genotypes and now we may be able to add selenium to the list.
