COX-2 inhibitors delay gastric wound healing in rats – (09-07-00)

COX-2 inhibitors delay gastric wound healing in rats

Evidence is starting to accumulate on the potential adverse effects of these new anti-inflammatories. This article suggests that, even though they lower your chances of getting an ulcer, COX-2 may hinder any ulcer that were already present from healing.

Journal of Gastroenterology and Hepatology 15 (7), 752-761 The present study demonstrated that cyclo-oxygenase-2 inhibitors delay gastric wound healing by suppressing expansion of the mucosal proliferative zone. These results provide evidence that cyclo-oxygenase-2 has an important role in gastric mucosal regeneration.