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Arthritis
Cyclo-Oxygenase 2 Function Is Essential for Bone Fracture Healing – (10-03-02)
James Bogash
Cyclo-Oxygenase 2 Function Is Essential for Bone Fracture Healing
This is a clinical decision nightmare. The newest arsenal in the fight against arthritis pain is the highly overused class of drugs called COX-2 selective inhibitors (Celebrex, Vioxx). These are supposed to be safer on the GI tract. Recent concerns have arisen over potential damage to the heart with their use, and now we see that the COX-2 enzyme is needed for proper bone healing. How many patients out there are improperly given the selective COX-2 inhibitors for pain relief following joint replacement surgery or fracture? Have to admit that those pharmaceutical reps are doing a good job pushing off-label uses for their drugs!
