MTHFR 677CtoT Polymorphism and Risk of Coronary Heart Disease
Chalk up another 16% risk for another modifiable risk factor (actually not modifiable but rather compensatable). Here we see that genetic variants with a sluggish enzyme that converts oral folic acid to its active form increases risk of CHD. So up your level of folic acid (at no additional cost because you’re already taking it to affect homocysteine levels…) to at least 400 mg (preferably 800 mg).
