Plasma IL-6 concentration is inversely related to insulin sensitivity, and acute-phase proteins associate with glucose and lipid metabolism in healthy subjects
What a tangled web we weave…It is known that insulin resistance leads to inflammation (hyperinsulinemia leads to increased TNF-alpha which turns on inflammation), but this study and several others point to the fact that inflammation also increases insulin resistance. So it becomes a feed forward cycle.
This is one of the reasons why I am against drug therapies like metformin because they do not address the overall levels of inflammation present in the body. Only by addressing lifestyle factors that contribute to inflammation (exercise, increased intake of omega 3 fatty acids, decreased intake of omega 6 fatty acids, heavy metal and chemical avoidance, increased fruits and veggies…) will we be able to control both the inflammation and the insulin resistance.
