Inflammation
OBESITY INCREASES RISK OF UV RADIATION INDUCED OXIDATIVE STRESS – (07-30-07)
Obesity increases the risk of UV radiation-induced oxidative stress and activation of MAPK and NF-B signaling
Chronic disease from alterations in physiology does not happen in a vacuum. Every alteration impacts all systems. This study, done in mice, finds that obese mice exposed to UV B light experienced greater oxidative damage. Given that obesity generates increased systemic inflammation which drains anti oxidant reserves, the inability to protect against another source of oxidative stress makes complete sense.
Take this in the context of the increased rates of melanoma in our kids. Is it from sun exposure as public health officials would have us believe–leading to recommendations for sun avoidance and Vit D deficiency? Or is a part of the picture relating to poor overall health?
