p53 Tumor Suppressor Down-Regulation by 17ß-Estradiol
The evidence continues to mount for estrogen being a carcinogen. Here we start seeing the potential biochemical reasoning for this outcome. Remember, however, that estrogen (as produced by the body) is a naturally occurring substance and serves its purpose. I firmly believe that the body, in its wisdom, down-regulates production of certain hormones as we age as a protective mechanism. Evidence strongly supports this theory for estrogen and HRT.
JCEM — Abstracts: Gao et al. 87 (8): 3915
