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Fish Oils
The ability of fish oil to suppress TNF alpha production – (08-05-02)
James Bogash
The ability of fish oil to suppress TNF alpha production
This is the future of medicine (like great-great-great grandchildrenish future…) where genetic differences are known to effect response rates to various interventions. TNF alpha up-regulates the immune system and TNF alpha blockade is one of the big new classes of disease modifying drugs for Crohn’s and rheumatoid arthritis. Here we see that different genetic polymorphisms in production of TNF alpha respond differently to fish oil supplementation. Genetic tests are already available for many known single nucleotide polymorphisms (SNiPS) that effect treatment response. Keep in mind that 6 g of fish oil is a high dosage.
AJCN — Abstracts: Grimble et al. 76 (2): 454
