Developmental origins of diabetes: The role of oxidative stress
This is not the first article to look at oxidative stress/mitochondrial dysfunction as the initiating factor of insulin resistance. The basic premise is that, due to poor nutrient intake coupled w/ genetic risk factors, the mitochondria in the cell (many articles specifically look at the muscle cell) begin to function poorly and can’t provide the energy needed for that cell to function properly. Hence begins the disruption of that cell’s ability to respond positively to insulin signalling.
