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Parkinson's
WHAT IS A GOOD SOLID BIOMARKER FOR PARKINSON DISEASE? – (03-28-05)
James Bogash
Urinary 8-hydroxydeoxyguanosine levels as a biomarker for progression of Parkinson disease
Following up on the previous article, the base problem with using a mitochondrial dysfunction/oxidative stress model is that we have not yet identified a good, solid, commercially available marker.
This article helps in that regards in suggesting that 8-OHDG, a marker of oxidative damage to DNA, may be a viable option. Interestingly and, not surprisingly, the treatment of choice for Parkinson’s, l-dopa, did not affect 8-OHDG levels.
